Health Alerts


Some family members have been diagnosed with a hereditary venous thrombotic (blood clot) risk factor in their blood called activated protein C resistance (APCR) or Factor V Leiden.

This genetic abnormality is inherited from either parent. Siblings and children of affected individuals have a 50% chance of inheriting the same defect and, in turn, if affected, they can pass it on to their children. This genetic abnormality is associated with a venous thrombotic (blood clot) risk only. Individuals who carry this defect and have never had a blood clot should conservatively be prophylaxed (receive therapy to decrease their risk) against venous blood clots during periods of high thrombotic risk, such as surgery or pregnancy. Women with this defect should not go on the birth control pill or hormone replacement therapy. This genetic abnormality is common at 4% - 6% of the general population in North America. Blood testing can be done to identify affected family members.

Last Updated: 2014-07-10
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